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Prozac and Suicide

Antidepressants appear to increase the risk of suicidal behavior in children and teenagers. Clinical studies have been conducted on suicide and Prozac, but it is difficult to know for sure if the medication actually causes suicidal thoughts or behavior. Certain people, however, may be at higher risk of suicidal behavior while taking antidepressants, including those with bipolar disorder or previous suicide attempts.

Prozac and Suicide: An Overview

Prozac® (fluoxetine hydrochloride) is a prescription medication used for the treatment of depression, obsessive-compulsive disorder (OCD), bulimia, and panic disorder. It is one of a group of medications called selective serotonin reuptake inhibitors (SSRIs). As with all antidepressants, there may be an increased risk of suicidal behavior when taking Prozac.
 

FDA Warning on Suicide With Prozac Use

The U.S. Food and Drug Administration (FDA) has issued a special warning about the risk of suicidal thinking and behavior with antidepressant use in children and teenagers. The warning was issued in response to concerns that antidepressants seemed to increase the risk of suicidal behavior in children and teenagers in clinical studies.
 

Does Prozac Cause Suicides?

In clinical studies, it did appear that there was a slightly increased risk of suicidal behavior in children and teenagers who took antidepressants, including Prozac.
 In one study, about 4 percent of children and teens taking an antidepressant had suicidal thoughts or behavior, compared to 2 percent in children and teens who were not taking an antidepressant.
 
This study looked at all suicidal behavior, including suicides, attempted suicides, and thoughts about committing suicide. It is important to note that no one in the study actually committed suicide.
 
It is difficult to know for sure if antidepressants cause suicidal behavior. To make matters more confusing, depression itself can cause such behavior. The bottom line: You should report any signs of suicidal behavior to your healthcare professional, whether you are taking an antidepressant or not.
 
Certain people seem to be at higher risk for this behavior while taking antidepressants. This includes people with bipolar disorder (or a family history of bipolar disorder) and people who have attempted suicide (or who have a family history of suicide attempts).
 
(Prozac and Suicide Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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