Prozac Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Prozac is combined with any of the drugs listed above.
Alprazolam (Xanax)
Taking Prozac with
alprazolam can increase the level of alprazolam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of alprazolam.
Aspirin
Taking Prozac and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and Prozac together.
Certain Antipsychotic Medications
Prozac can increase the level of certain
antipsychotic medications in your blood and can increase your risk of side effects. Your healthcare provider may need to lower your dose of antipsychotic medicine.
Pimozide and
thioridazine should never be taken with Prozac. In fact, you should not take thioridazine if you have taken Prozac within the past five weeks.
Certain Seizure Medications
Taking Prozac with certain
seizure medications (
carbamazepine and
phenytoin) can increase the level of the
seizure medication in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of seizure medication.
Diazepam (Valium)
Taking Prozac with
diazepam can increase the level of diazepam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of diazepam.
Digoxin (Digitek, Lanoxin)
Taking Prozac and
digoxin together can increase your risk of
digoxin side effects. Your healthcare provider may need to adjust your digoxin dose when starting or stopping Prozac.
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