Prozac Drug Interactions

Medications That Prolong the QT Interval
Many different medications, including Prozac, can cause a change in the heart rhythm known as QT prolongation, which can be very dangerous. Combining Prozac with other QT-prolonging medications increases the risk of a life-threatening arrhythmia (torsade de pointes) caused by excessive QT prolongation. Check with your healthcare provider before combining such medications.
 
Miscellaneous Antidepressants
Combining Prozac with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking Prozac and an MAOI together can cause life-threatening side effects. Never take an MAOI and Prozac at the same time, and do not take Prozac if you have taken an MAOI within the past 14 days. Also, because Prozac stays in your system for so long, do not take an MAOI if you have taken Prozac within the past five weeks.
 
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Prozac and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking NSAIDs and Prozac together.
 
SSRI or SNRI Antidepressants
Taking Prozac with other SSRI or SNRI antidepressants can cause serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking Prozac with St. John's wort can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
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Prozac Information

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