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Sinequan Drug Interactions

It is important to know that while you are on Sinequan, drug interactions may occur if you take it with alcohol, cimetidine, or other tricyclic antidepressants. These drug interactions can cause serious side effects, such as suicidal thoughts, low blood sugar, or dangerous irregular heart rhythms. Other medications that may potentially lead to Sinequan interactions include monoamine oxidase inhibitors, SSRI antidepressants, arrhythmia medications, and tolazamide.

 

Sinequan Drug Interactions: An Introduction

 Sinequan® (doxepin hydrochloride) can potentially interact with many medicines. Some of the medicines that may lead to Sinequan interactions include:
 
  • Alcohol
     
  • Anticholinergic medications, including:
o Atropine
o Belladonna (Donnatal®, B&O Supprettes®, Bellamine S®)
o Clidinium (Librax®)
o Diphenhydramine (Benadryl®, Tylenol PM®)
o Glycopyrrolate (Robinul®)
o Homatropine (Hycodan®)
o Hyoscyamine (Levsin®)
o Scopolamine (Transderm Scop®)
  • Arrhythmia medications, including:
o Amiodarone (Cordarone®)
o Disopyramide (Norpace®)
o Dofetilide (Tikosyn®)
o Flecainide (Tambocor®)
o Ibutilide (Corvert®)
o Propafenone (Rythmol®)
o Quinidine
o Sotalol (Betapace®)
  • Phenothiazine medications, including:
o Promethazine (Phenergan®)
(Sinequan Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;