Sinequan is a prescription medicine that is licensed for the treatment of depression and anxiety. It is believed that the medication works by allowing certain chemicals in the brain (serotonin and norepinephrine) to stay in the brain longer. Potential side effects of the antidepressant may include drowsiness, dizziness, or difficulty urinating. While there is currently no brand-name version available, generics are available in the forms of capsules and a liquid.

What Is Sinequan?

Sinequan® (doxepin hydrochloride) is a prescription medication that is used to treat depression (also known as major depression or clinical depression). It is also approved to treat anxiety.
(Click Sinequan Uses for more information on what the medicine is used for, including possible off-label uses.)

What Makes It?

Sinequan was originally made by Pfizer. However, brand-name Sinequan is no longer available. Generic versions are still available and are made by several manufacturers of generic medications.

How Does Sinequan Work?

Sinequan belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how the medicine works, but it does affect several chemicals in the brain (including serotonin and norepinephrine). It is thought that perhaps Sinequan allows these chemical to stay in the brain longer, which can help with depression symptoms and anxiety. The drug can also block histamine receptors, making it useful as an antihistamine.
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Sinequan (Doxepin)

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