Sinequan
® (
doxepin hydrochloride) is a prescription medication that is used to treat
depression (also known as major depression or clinical depression). It is also approved to treat
anxiety.
(Click Sinequan Uses for more information on what the medicine is used for, including possible off-label uses.)
Sinequan was originally made by Pfizer. However, brand-name Sinequan is no longer available. Generic versions are still available and are made by several manufacturers of generic medications.
Sinequan belongs to a class of medications called
tricyclic antidepressants. It is not entirely clear how the medicine works, but it does affect several chemicals in the brain (including serotonin and norepinephrine). It is thought that perhaps Sinequan allows these chemical to stay in the brain longer, which can help with depression symptoms and anxiety. The drug can also block histamine receptors, making it useful as an antihistamine.