Tofranil Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when Tofranil is combined with any of the drugs listed above.

 

Tofranil may enhance the effects of alcohol. This can lead to an increased risk for suicidal thoughts and overdose symptoms. Talk with your healthcare provider about drinking alcohol while taking this medication.

 

Taking Tofranil with anticholinergic medications may cause increased side effects. Talk to your healthcare provider before using these medications together, as your dosages may need to be reduced. Since anticholinergic medications are found in some over-the-counter medicines, do not treat yourself for the common cold, a cough, or allergies without first talking to your healthcare provider.

 

Combining Tofranil with arrhythmia medications can increase your risk of a dangerous arrhythmia called QT prolongation. Also, certain arrhythmia medications can increase the level of Tofranil in your blood, which may increase your risk of side effects. Talk to your healthcare provider before taking these medications together.

 

If Tofranil is taken with barbiturates, this can increase the risk of side effects of both Tofranil and barbiturates (such as drowsiness or dizziness). Also, barbiturates may decrease the level of Tofranil in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications to prevent this particular interaction from occurring.

 

Tofranil can make certain blood pressure mediations, such as clonidine (Catapres^®), less effective. Also, taking Tofranil with high blood pressure medications may increase your chance of low blood pressure (hypotension). To prevent drug interactions, talk with your healthcare provider before taking Tofranil with a blood pressure medication.