Tofranil Drug Interactions

Barbiturates
If Tofranil is taken with barbiturates, this can increase the risk of side effects of both Tofranil and barbiturates (such as drowsiness or dizziness). Also, barbiturates may decrease the level of Tofranil in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your dose of these medications to prevent this particular interaction from occurring.
 
Blood Pressure Medications
Tofranil can make certain blood pressure mediations, such as clonidine (Catapres®), less effective. Also, taking Tofranil with high blood pressure medications may increase your chance of low blood pressure (hypotension). To prevent drug interactions, talk with your healthcare provider before taking Tofranil with a blood pressure medication.
 
Buspirone (BuSpar)
Because combining Tofranil with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine
Taking Tofranil with cimetidine can increase the level of Tofranil in your blood, possibly increasing your chance of side effects. Depending on your situation, your healthcare provider may need to adjust your dose of these medications.
 
Fentanyl
Combining Tofranil with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking Tofranil with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Lithium
Combining Tofranil with lithium may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
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Tofranil (Imipramine)

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