Drug Interactions With Trazodone

Carbamazepine
Carbamazepine can decrease the level of trazodone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of trazodone.
 
Digoxin
Taking digoxin with trazodone may increase the level of digoxin in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of digoxin in your blood, especially when starting or stopping trazodone.
 
Fentanyl
Taking trazodone with fentanyl can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Intravenous Methylene Blue
Taking trazodone with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Trazodone should not be started in people taking linezolid or IV methylene blue, but a person already taking trazodone may be given linezolid or methylene blue, if absolutely necessary, and only with very careful monitoring and only if trazodone is stopped during treatment.
 
Linezolid
Taking trazodone with linezolid can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Lithium
Taking trazodone with lithium can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
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