Monoamine Oxidase Inhibitors
It is not known if
trazodone interacts with MAOIs. However, since many other
antidepressants interact with them, your healthcare provider may want to monitor you more closely if you are taking these two medications together.
Nefazodone
Combining trazodone with
nefazodone may increase the level of trazodone in your blood, which may increase your risk of side effects. To prevent this, your healthcare provider may need to lower your
trazodone dosage.
Nicardipine
If trazodone and
nicardipine are taken together, this may increase the level of trazodone in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your trazodone dosage to prevent this interaction from occurring.
Phenytoin
Taking
phenytoin with trazodone may increase the level of phenytoin in your blood, which can increase your risk of side effects. Depending on your situation, your healthcare provider may need to monitor the level of phenytoin in your blood, especially when starting or stopping trazodone.
Protease Inhibitors
If trazodone is combined with protease inhibitors, this may increase the level of trazodone in your blood, which may increase your risk of side effects. To prevent this, your healthcare provider may need to lower your trazodone dosage.
Quinidine
Taking trazodone with quinidine may increase the level of trazodone in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your trazodone dosage to prevent this.
Final Thoughts on Drug Interactions With Trazodone
It is possible that not all drug interactions with trazodone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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