Drug Interactions With Trazodone

Miscellaneous Antidepressants
Combining trazodone with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Monoamine Oxidase Inhibitors (MAOIs)
You should not take trazodone and an MAOI within 14 days of each other, as serious side effects could result.
 
Phenytoin
Taking phenytoin with trazodone may increase the level of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor the level of phenytoin in your blood, especially when you are starting or stopping trazodone.
 
Sibutramine
Taking trazodone with sibutramine can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 
SSRI or SNRI Antidepressants
Taking trazodone with SSRI or SNRI antidepressants can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
 
St. John's Wort
Taking trazodone with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see Precautions and Warnings With Trazodone), as it can be very dangerous.
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