How Does Trazodone Work?
Although it is used to treat depression, trazodone hydrochloride (Desyrel®) is not a selective serotonin reuptake inhibitor (SSRI) antidepressant. No other medications work exactly like it, so it is not entirely clear how trazodone works. The medication does help block the reuptake of serotonin so that more is available for the nerves in the brain, returning the serotonin back to its "normal" levels (SSRIs also do this). Trazodone may also block certain serotonin receptors.
(For more details on how this medication works, click Trazodone. This overview article takes an in-depth look at this drug and its uses, covering topics such as side effects, dosing guidelines, available strengths, and more.)