Trazodone can potentially interact with a number of medicines (see Drug Interactions With Trazodone).
You should talk with your healthcare provider prior to taking this drug if you have:
- Bipolar disorder or a family history of bipolar disorder (also known as manic depression)
- Heart disease
- A recent history of heart attack
- A history of suicide attempts or suicidal thoughts
- An upcoming surgery
- Any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- Pregnant or thinking of becoming pregnant (see Trazodone and Pregnancy)
Make sure to tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Trazodone to learn more, including information on who should not take the drug.)
Depression, even in its most severe form, is highly treatable. As with many illnesses, getting treatment for depression early is more effective and reduces the chance of recurrence.
The most common forms of treatment for depression are medication (antidepressants) and psychotherapy ("talk therapy"). In some cases of severe depression, healthcare providers may recommend electroconvulsive therapy (ECT). Some people may also try complementary or alternative treatments for depression (see Natural Remedies for Depression).
Trazodone is generally quite effective at treating depression. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, your healthcare provider may recommend an alternative to trazodone. Examples of alternate medications for depression include:
- Selective serotonin reuptake inhibitors (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
- Norepinephrine and dopamine reuptake inhibitors (NDRIs)
- Tricyclic antidepressants
- Monoamine oxidase inhibitors (MAOIs).
(Click Trazodone Alternatives to learn more about these alternatives or click Dealing With Depression to learn about other ways of managing depression.)