Drug Interactions With Trimipramine

Buspirone (BuSpar)
Because combining trimipramine with buspirone may increase the risk of serotonin syndrome, check with your healthcare provider before taking these medications together.
 
Cimetidine (Tagamet)
Taking trimipramine with cimetidine can raise the level of trimipramine in your blood, increasing your chances of side effects. If you are taking trimipramine with cimetidine, your healthcare provider may need to adjust your doses of these medications.
 
Fentanyl
Combining trimipramine with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Intravenous Methylene Blue
Taking trimipramine with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Linezolid (Zyvox)
Taking trimipramine with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking trimipramine with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining trimipramine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking trimipramine with MAOIs can increase your chances of developing dangerous side effects. Do not take trimipramine if you have taken an MAOI within the past two weeks.
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