What Is Trimipramine Used For?

How Trimipramine Works

Trimipramine is a tricyclic antidepressant. Tricyclic antidepressants are an older group of medications that have been used to treat depression for many years. Even though trimipramine has been around for a long time, it is not entirely clear how it works. Trimipramine affects several chemicals in the brain, including serotonin and norepinephrine.

Is Trimipramine Used in Children and Teens?

Trimipramine is not recommended for use in people less than 18 years old, as it has not been thoroughly studied in children or teens. Antidepressants have been shown to increase the risk of suicidal thinking and behavior in short-term research studies involving children and teenagers (see Surmontil and Suicide for more information on the risks of suicide with trimipramine). Talk with your healthcare provider about treatment options for childhood or teen depression.

Is Trimipramine Used Off-Label?

On occasion, your healthcare provider may recommend trimipramine for treating something other than depression. This is called an "off-label" use. At this time, there are several off-label trimipramine uses, including:
  • Chronic pain: Trimipramine works best for chronic pain that is nerve-related, such as nerve pain from having shingles (including postherpetic neuralgia).
  • Anxiety disorder: Many antidepressants (including trimipramine) are used to treat anxiety disorders.
  • Bedwetting: Trimipramine has been used to help people stop bedwetting.
  • Attention deficit hyperactivity disorder (ADHD): Trimipramine can be used to treat ADHD, especially if other ADHD medications have not been effective or have caused side effects.
  • Fibromyalgia: Trimipramine has been used to treat pain and other symptoms of fibromyalgia.
  • Prevention of migraine headaches: Trimipramine can be used on a daily basis to prevent migraine headaches. It is not effective for treating a migraine headache once it starts.
  • Treatment for bulimia: Trimipramine can help improve bulimia symptoms, including binge eating and vomiting.
  • Trimipramine is sometimes used to help people quit smoking.
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Trimipramine (Surmontil)

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