Drug Interactions With Venlafaxine XR

Cimetidine (Tagamet)
Taking cimetidine and venlafaxine XR together can increase the level of venlafaxine XR in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your venlafaxine XR dose or may suggest an alternative to cimetidine. However, this interaction is usually not a problem (except for people with high blood pressure or liver problems).
 
Fentanyl
Combining venlafaxine XR with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Haloperidol (Haldol)
Taking venlafaxine XR with haloperidol can raise the level of haloperidol in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your haloperidol dosage.
 
Indinavir (Crixivan)
Taking venlafaxine XR with indinavir may decrease the level of indinavir in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to increase your dose of indinavir.
 
Intravenous Methylene Blue
Taking venlafaxine XR with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole (Nizoral)
Taking venlafaxine XR with ketoconazole may raise the level of venlafaxine XR in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your venlafaxine XR dosage.
 
Linezolid (Zyvox)
Taking venlafaxine XR with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucinations, a fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
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Venlafaxine Sustained Release

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