Drug Interactions With Venlafaxine

Fentanyl
Combining venlafaxine with fentanyl may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together.
 
Haloperidol (Haldol)
Taking venlafaxine with haloperidol can raise the level of haloperidol in your blood, increasing your risk of side effects. If you are taking these drugs together, your healthcare provider may need to decrease your haloperidol dosage.
 
Indinavir (Crixivan)
Taking venlafaxine with indinavir may decrease the level of indinavir in your blood, perhaps making it less effective. If you are taking these drugs together, your healthcare provider may need to increase your dose of indinavir.
 
Intravenous Methylene Blue
Taking venlafaxine with intravenous methylene blue can increase your chance of developing dangerous side effects, including serotonin syndrome. Do not take these medications together.
 
Ketoconazole (Nizoral)
Taking venlafaxine with ketoconazole may increase the level of venlafaxine in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your venlafaxine dosage.
 
Linezolid (Zyvox)
Taking venlafaxine with linezolid can cause a group of symptoms called serotonin syndrome. These symptoms can include confusion, hallucination, fast heartbeat, feeling faint, a fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
 
Lithium (Eskalith, Lithobid)
Taking venlafaxine with lithium can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Miscellaneous Antidepressants
Combining venlafaxine with other antidepressants may increase the risk of serotonin syndrome. Check with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
  
Monoamine Oxidase Inhibitors (MAOIs)
Taking venlafaxine and an MAOI together can cause life-threatening side effects. Do not take venlafaxine if you have taken an MAOI within the past two weeks. Also, do not take an MAOI if you have taken venlafaxine within the past seven days.
 
SSRI or SNRI Medications
Taking venlafaxine with other SSRI or SNRI medicines can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
St. John's Wort
Taking venlafaxine with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tramadol (Rybix ODT, Ryzolt, Ultram, Ultram ER) or Tramadol and Acetaminophen (Ultracet)
Taking venlafaxine with tramadol can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tricyclic Antidepressants
Taking venlafaxine with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
 
Triptans
Taking venlafaxine with a triptan can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
Tryptophan
Taking venlafaxine with tryptophan can cause a group of symptoms called serotonin syndrome. Talk with your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome (see above), as it can be very dangerous.
 
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