By allowing certain chemicals to stay in the brain for a longer period of time, venlafaxine hydrochloride (Effexor^®) can help treat depression. Venlafaxine comes in tablet form and is taken two or three times a day. Although most people tolerate venlafaxine well, there are some potential side effects of the medication, such as insomnia, dry mouth, and nausea. Venlafaxine is not suitable for everyone. Before starting this prescription medication, make sure your healthcare provider is aware of your medical history and any other medications you are taking (including vitamins and supplements).