Wellbutrin SR Drug Interactions

Wellbutrin SR Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Wellbutrin SR is combined with any of the drugs listed above.
 
Alcohol
It is not recommended that you drink alcohol while taking Wellbutrin SR. Combining alcohol and Wellbutrin SR together may cause unwanted side effects (see Wellbutrin SR and Alcohol). However, since stopping alcohol abruptly while taking Wellbutrin SR can increase your risk of seizures, you should talk with your healthcare provider before you stop drinking alcohol.
 
Other Antidepressants
Taking Wellbutrin SR with other antidepressants may affect the levels of Wellbutrin SR and other antidepressants in your blood, increasing your risk of side effects. Also, taking Wellbutrin SR with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining Wellbutrin SR with other antidepressant medications.
 
You should not take Wellbutrin SR along with other products containing bupropion, including Aplenzin™, Budeprion SR®, Buproban®, Budeprion XL®, Forfivo™ XL, Wellbutrin®, Wellbutrin XL®, and Zyban®.
 
Amantadine (Symmetrel)
Taking Wellbutrin SR and amantadine together may increase your risk of side effects. Your healthcare provider may decide to start you at a lower Wellbutrin SR dose if you are taking amantadine.
 
Antipsychotic Medications
Wellbutrin SR can raise the levels of some antipsychotic medications in your blood, increasing your risk of side effects. Also, taking Wellbutrin SR with antipsychotic medications may increase your chances of seizures. Talk with your healthcare provider before taking these medications together.
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