Wellbutrin SR Warnings and Precautions

Some Wellbutrin SR Warnings and Precautions

Some warnings and precautions to be aware of with Wellbutrin SR include:
  • Antidepressants (including Wellbutrin SR) may increase the risk of suicidal thoughts or behavior in children, teenagers, and adults (see Antidepressants and Suicide for more information). Therefore, you should talk with your healthcare provider immediately if you notice any changes in symptoms or develop any new symptoms while taking Wellbutrin SR. Some of these symptoms may include anxiety, hostility, agitation, panic, restlessness, hallucinations, extreme hyperactivity, and suicidal thoughts or behaviors (see Wellbutrin SR and Suicide for more information).


  • Before prescribing Wellbutrin SR for depression, your healthcare provider should make sure that you do not have bipolar disorder (instead of depression). Sometimes, the symptoms of bipolar disorder and depression are very similar, and Wellbutrin SR can cause problems in people with bipolar disorder.
  • Wellbutrin SR can increase the risk of seizures. Because of this, there are certain people who should not take Wellbutrin SR, including people with:



  • Also, people taking certain medications (see Wellbutrin SR Drug Interactions) have a higher risk of seizures. Abruptly stopping alcohol or sedative medications can also increase your chances of seizures.


  • To avoid seizures, you should not take more than 400 mg of Wellbutrin SR per day, and each individual dose should not be greater than 200 mg (see Wellbutrin SR Dosage).
  • Wellbutrin SR should not be used right after a heart attack. Also, there is some evidence that Wellbutrin SR can cause irregular heart rhythms (arrhythmias) in people with heart disease.


  • Wellbutrin SR has been reported to cause false positives on some amphetamine drug screening tests, even after people have stopped taking Wellbutrin SR. 


  • Wellbutrin SR can cause liver damage. Also, since the liver and kidneys aid in removing Wellbutrin SR from the blood, you should talk with your healthcare provider before taking Wellbutrin SR if you have liver or kidney problems.
  • Wellbutrin SR can cause insomnia, agitation, hallucinations, confusion, and other mental problems, especially in people just starting Wellbutrin SR. Tell your healthcare provider if you are experiencing any of these problems.
  • Wellbutrin SR can cause weight loss. This can be a problem for some people, especially those who are underweight (see Wellbutrin SR and Weight Loss for more information).
  • Wellbutrin SR can cause allergic reactions. Tell your healthcare provider if you have signs of an allergic reaction -- including an unexplained skin rash, itching, hives, trouble breathing, or unexplained swelling -- while taking Wellbutrin SR.
  • Sometimes Wellbutrin SR can cause high blood pressure (hypertension), especially in people using nicotine patches. Your healthcare provider should monitor your blood pressure if you are taking Wellbutrin SR. It is not known if Wellbutrin SR causes problems in people who have heart disease or who have recently had a heart attack.
  • Wellbutrin SR is a considered a pregnancy Category C medication. This means that Wellbutrin SR may not be safe to use during pregnancy. Talk with your healthcare provider about the risks and benefits of using Wellbutrin SR during pregnancy (see Wellbutrin SR and Pregnancy for more information).
  • Wellbutrin SR passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, be sure to talk with your healthcare provider about using Wellbutrin SR (see Bupropion and Breastfeeding).
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