Wellbutrin XL Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when Wellbutrin XL is combined with any of the drugs listed above.

 

People are generally advised to avoid alcohol while taking Wellbutrin XL. Combining the two may cause unwanted side effects (see Wellbutrin XL and Alcohol). However, because stopping alcohol abruptly while taking the drug can increase your risk of seizures, talk to your healthcare provider before you stop drinking alcohol.

 

Taking Wellbutrin XL with other antidepressants may affect the level of Wellbutrin XL and the other antidepressant in your blood, thereby increasing your risk of side effects. Also, taking Wellbutrin XL with other antidepressants may increase your risk of seizures. Talk with your healthcare provider before combining Wellbutrin XL with other antidepressant medications.

 

You should not take Wellbutrin XL with other products containing bupropion, including Aplenzin™, Budeprion SR^®, Budeprion XL^®, Buproban^®, Forfivo™ XL, Wellbutrin^®, Wellbutrin SR^®, and Zyban^®.

 

Combining Wellbutrin XL and amantadine may increase your risk of side effects. Your healthcare provider may decide to start you at a lower Wellbutrin XL dosage if you are taking amantadine.

 

Wellbutrin XL can increase the level of some antipsychotic medications in your blood, which may increase your risk of side effects. Also, taking Wellbutrin XL with antipsychotic medications may increase your chance of seizures. Talk with your healthcare provider before taking these medications together.