Wellbutrin XL Drug Interactions

Beta Blockers
Wellbutrin XL may increase the level of beta blockers in your blood, potentially increasing your risk of side effects. Depending on your situation, your healthcare provider may need to monitor you more closely and may need to decrease your dose of beta blockers.
 
Certain Arrhythmia Medications
Wellbutrin XL may increase the level of certain arrhythmia medications in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to monitor you more closely, especially when starting or stopping Wellbutrin XL.
 
Clopidogrel
Clopidogrel may slow the metabolism of Wellbutrin XL in the body, potentially leading to high levels of Wellbutrin XL and a potentially higher risk of Wellbutrin XL side effects. Check with your healthcare provider before taking these medications together.
  
Cyclophosphamide
Cyclophosphamide may interact with Wellbutrin XL, although there have been no reports of such an interaction in actual patients. Depending on your situation, your healthcare provider may need to monitor you more closely and may need to adjust your dose of these medications.
 
Doxorubicin
Doxorubicin may increase the level of Wellbutrin XL in your blood, possibly increasing your chance of side effects. Your healthcare provider may need to decrease your Wellbutrin XL dose while you are taking doxorubicin.
 
Efavirenz
Efavirenz may increase the metabolism of Wellbutrin XL, leading to decreased levels of Wellbutrin XL in the blood, and possibly to decreased effectiveness. Check with your healthcare provider before taking such medications together. You may need a higher Wellbutrin XL dosage, although the maximum recommended dosage should not be exceeded, even if you are taking efavirenz.
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Wellbutrin XL Drug Information

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