Wellbutrin XL^® (bupropion XL) is often prescribed to treat symptoms of depression and seasonal affective disorder, which can be caused when certain chemicals of the brain become unbalanced. The medication allows certain chemicals (dopamine and norepinephrine) to stay in the brain longer. It comes in tablet form, and is taken once a day in the morning. Because Wellbutrin XL can interact with other medications, tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.