Wellbutrin Substitute

Wellbutrin^® (bupropion hydrochloride) is a medication used for treating depression (also known as major depression or clinical depression). Although Wellbutrin can be effective in treating this condition, for some people it does not work or may cause side effects. Fortunately, there are several substitutes for Wellbutrin. Some of these substitutes include:

Therapy
Other depression medications (also known as antidepressants)
Electroconvulsive therapy
Alternative (natural) therapies.

Some of the medications that are considered alternatives to Wellbutrin include:

Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Selective serotonin reuptake inhibitors (SSRIs)
Monoamine oxidase inhibitors (MAOIs)
Tricyclic antidepressants
Miscellaneous other antidepressants.

Some people may also consider complementary or alternative treatments for depression, such as:

Acupuncture
St. John's wort
Omega-3 fatty acids
Vitamin B₆
SAMe (S-adenosyl-L-methionine)
5-HTP (5-hydroxytryptophan)
Valerian.

In situations where medication, therapy, and the combination of these treatments prove ineffective, or work too slowly to relieve severe symptoms, electroconvulsive therapy (ECT) may be considered.

If Wellbutrin is not working for you or if it is causing bothersome side effects, ask your healthcare provider about trying a Wellbutrin substitute.

(Click Wellbutrin Alternatives for a more in-depth look at Wellbutrin substitutes, such as therapy, other medications, and alternative natural therapies. This article also explains when it may be time to consider a substitute for Wellbutrin.)