Zoloft was studied in two clinical trials for premenstrual dysphoric disorder (PMDD). These two studies did not include women on oral contraceptives (birth control pills). One study looked at using the drug every day for PMDD. The second study looked at using it only for the last two weeks of the menstrual cycle. Both studies showed that Zoloft was beneficial in treating PMDD.
As a type of selective serotonin reuptake inhibitor (SSRI), Zoloft works by acting on a specific chemical within the brain known as serotonin. When levels of serotonin become unbalanced, this can cause a variety of conditions, including depression. Zoloft helps to block the reuptake of serotonin so that more remains in the space between the brain's nerve cells.
(Click Zoloft and What Is Zoloft Used For? for a more in-depth look at the benefits of Zoloft, including information on how it works and how it can help relieve symptoms of several conditions.)