Zoloft^® (sertraline hydrochloride) is a prescription medication approved for treating depression, panic disorder, obsessive-compulsive disorder, and other conditions within the brain. By balancing the level of a certain chemical in the brain (serotonin), the drug can help reduce symptoms and prevent relapses. Zoloft comes in both tablet and liquid form, and is available in several strengths. Potential side effects include diarrhea, nausea, and drowsiness.