Hair loss is an infrequent side effect of Zoloft^® (sertraline hydrochloride). Hair loss occurs in between 1 in 100 and 1 in 1,000 people who take Zoloft. If you experience hair loss while taking Zoloft, talk with your healthcare provider. Depending on how severe the hair loss is, there are things that he or she may be able to do. It is possible that if hair loss is bothersome to you, your doctor may recommend adjusting the Zoloft dosage or trying another medicine for your condition.