Zoloft Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Zoloft is combined with any of the drugs listed above.
Alcohol
According to the prescribing information, drinking alcohol while taking Zoloft is not recommended. Combining the two may cause unwanted side effects
(see Alcohol and Zoloft).
Aspirin
Taking Zoloft and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before combining these medications.
Certain Arrhythmia Medications
Taking Zoloft with certain arrhythmia medications can increase the level of arrhythmia medication in your blood, increasing your risk of side effects. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications.
Cimetidine (Tagamet)
Combining
cimetidine and Zoloft can increase the level of Zoloft in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to lower your
Zoloft dosage or may suggest an alternative to cimetidine.
Digoxin (Digitek, Lanoxin)
Taking Zoloft and
digoxin together may increase your risk of side effects with either drug. Your healthcare provider may need to adjust your dose of these medications to prevent interactions from occurring.
Disulfiram (Antabuse)
You should not take
Zoloft oral concentrate (the liquid version) while taking disulfiram. Because the oral concentrate contains 12 percent alcohol, taking it with disulfiram will cause severe side effects.
Linezolid (Zyvox)
Combining Zoloft with a
linezolid can cause a group of symptoms called serotonin syndrome. These symptoms may include:
- Confusion
- Hallucination
- Fast heartbeat
- Feeling faint
- Fever
- Sweating
- Muscle spasm
- Difficulty walking
- Diarrhea.
Talk to your healthcare provider before taking Zoloft and a linezolid. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be dangerous.
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