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Zoloft Drug Interactions

In the case of Zoloft, drug interactions may occur with medications such as lithium, pimozide, and aspirin. Other possible drug interactions with Zoloft involve medications such as warfarin, ibuprofen, and linezolid. Some Zoloft drug interactions can cause a group of symptoms called serotonin syndrome, which can be very dangerous. Alcohol and Zoloft can also interact, causing unwanted side effects.

 

Zoloft Drug Interactions: An Introduction

 Zoloft® (sertraline hydrochloride) potentially has a number of other medicines with which it may interact. Some of these Zoloft drug interactions can involve:
 
  • Alcohol
  • Aspirin
  • Certain arrhythmia medications, including propafenone (Rythmol®), flecainide (Tambocor®), and quinidine.
  • Cimetidine (Tagamet®)
  • Digoxin (Digitek®, Lanoxin®)
  • Disulfiram (Antabuse®)
  • Linezolid (Zyvox®)
  • Lithium (Eskalith®, Lithobid®)
  • Monoamine oxidase inhibitors (MAOIs), including:
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
o Ibuprofen (Motrin®, Advil®)
o Diclofenac (Cataflam®, Voltaren®)
  • Tryptophan
  • Warfarin (Coumadin®, Jantoven®).
     
(Zoloft Drug Interactions Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;