Zoloft for Premature Ejaculation

Healthcare providers may sometimes treat premature ejaculation with Zoloft, even though the medication is not approved for this use. One of the possible side effects of Zoloft is delayed ejaculation; while this is usually an undesired side effect, it may benefit those men who experience problems with premature ejaculation.

Zoloft for Premature Ejaculation: An Overview

Zoloft® (sertraline hydrochloride) is a prescription medicine used for the treatment of the following conditions:
However, Zoloft is sometimes used to treat premature ejaculation, although it is not approved for this use. This is known as an "off-label" use of the medication.

How Is Premature Ejaculation Treated With Zoloft?

It is not entirely clear how this drug works for premature ejaculation. Premature ejaculation occurs when a man uncontrollably ejaculates too soon (either before or just after sexual penetration). As with other similar antidepressants, Zoloft is known to cause sexual side effects, including delayed ejaculation. While these sexual side effects are usually undesired, in the case of men with premature ejaculation, the Zoloft sexual side effects can help to delay their ejaculation.
When this medicine is used for premature ejaculation, this is considered an "off-label" use. An off-label use of a prescription medicine involves using the medication to treat a disease or condition for which the drug has not been approved by the U.S. Food and Drug Administration (FDA).
Although the FDA regulates how a medication can be advertised or promoted by the manufacturer, these regulations do not restrict a healthcare provider's ability to prescribe the medication for different conditions, in different doses, or for different lengths of time than those approved by the FDA. Your healthcare provider will prescribe a medicine for off-label use when he or she feels that the medicine is appropriate for your situation.
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