Zoloft has been studied in numerous clinical trials for several conditions. Clinical studies have shown the drug to be effective for treating depression, OCD, panic disorder, post-traumatic stress disorder, and social anxiety disorder in adults. Also, long-term studies showed that people taking it were less likely to have a relapse.
The medication has been shown to be effective for treating OCD in children as young as six years old. It has not been studied in children or teens for any other use.
Zoloft was studied in two clinical trials for premenstrual dysphoric disorder (PMDD). These two studies did not include women on oral contraceptives (birth control pills). One study looked at using the drug every day for PMDD. The second study looked at using it only for the last two weeks of the menstrual cycle. Both studies showed that Zoloft was effective for treating PMDD.
Some suggestions on how and when to take Zoloft include the following:
- The medication comes in tablet and liquid form. You take it by mouth -- usually once a day.
- Zoloft oral concentrate (the liquid form) must be diluted before each use. Measure the correct amount, then mix it with 4 ounces (half a cup) of water, ginger ale, lemon-lime soda, lemonade, or orange juice. Do not mix the oral concentrate with any other beverages. Also, mix the oral concentrate immediately before taking it -- do not prepare it far ahead of the time you intend to take it.
- If the medication makes you drowsy, try taking it before bedtime. If it causes insomnia, try taking it in the morning.
- You can take Zoloft with or without food. If the medication bothers your stomach, try taking it with food.
- Take Zoloft at the same time each day to maintain an even level in your blood.
- For the medication to work properly, you must take it as prescribed. Zoloft will not work if you stop taking it.