Medications
 
 

Zoloft Substitute

 Zoloft® (sertraline hydrochloride) is a prescription medicine approved to treat various conditions within the brain, including depression, post-traumatic stress disorder, and obsessive-compulsive disorder.
 
Most people tend to respond well to this medication. If your symptoms do not improve or you develop bothersome side effects, however, you may want to consider a substitute for Zoloft. Several other drugs are available to treat depression, including:
 
Besides other antidepressants, there are several other alternatives to Zoloft for depression treatment, including:
 
  • Therapy
  • Electroconvulsive therapy
  • Alternative (natural) therapies.
     
Since there are so many options available, make sure to talk to your healthcare provider to find the best Zoloft substitute for your situation.
 
(Click Zoloft Alternatives to learn more about the different types of therapy that are available and to find out which medications belong to each class of antidepressants.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD