Depression Home > Trazodone and Dry Mouth

Side effects may occur with the use of trazodone, and dry mouth is one of the most common. To relieve this, you can try avoiding tobacco or alcohol, sipping water or sugarless drinks often, and avoiding drinks with caffeine. If you are taking trazodone and dry mouth becomes severe, your healthcare provider may adjust your dosage or recommend another antidepressant.

Trazodone and Dry Mouth: An Overview

Dry mouth is one of the most common side effects of trazodone hydrochloride (Desyrel®). In studies, up to 33.8 percent of people reported dry mouth as one of the trazodone side effects, compared to 20.3 percent of people who were not taking the drug.

Trazodone and Dry Mouth: Recommendations

If you are taking trazodone and dry mouth occurs, there are some things that you can do to help relieve this. Some of these suggestions include:
  • Sip water or sugarless drinks often.
  • Sip water or sugarless drinks during meals. This will make chewing and swallowing easier. It may also improve the taste of food.
  • Avoid drinks with caffeine, such as coffee, tea, and some sodas. Caffeine can dry out the mouth.
  • Don't use tobacco or alcohol. They dry out the mouth.
  • Use a humidifier at night.
  • Be aware of spicy or salty foods. These may cause pain in a dry mouth.
  • Chew sugarless gum or suck on sugarless, hard candy to stimulate saliva flow; cinnamon or mint-flavored candies are good choices.

Trazodone and Dry Mouth: Final Thoughts

If you develop a dry mouth while taking trazodone, and the suggestions in this article do not help, talk with your healthcare provider. He or she may be able to recommend treatments, such as artificial saliva. Also, depending on how severe the dry mouth is, he or she may also make adjustments to your trazodone dosing or recommend another antidepressant.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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