Depression Home > Trazodone Dosage

When first beginning treatment with trazodone, dosing guidelines generally call for 150 mg a day. Depending on your response to the medication, the dosage can be increased up to 400 mg per day (or 600 mg for those who are being treated in the hospital). When treating insomnia with trazodone, the dose is usually 25 mg to 50 mg at bedtime.

An Introduction to Trazodone Dosing

The dose of trazodone hydrochloride (Desyrel®) your healthcare provider prescribes will vary, depending on a number of factors, including:
  • Your age
  • Other medical conditions you may have
  • Other medications you are currently taking.
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.

Dose of Trazodone for Depression

The recommended starting trazodone dosage when treating depression is 150 mg per day (divided into two or three doses per day). Your healthcare provider may choose to increase the dose if symptoms continue, or decrease the dose if trazodone side effects occur. The maximum recommended dose of trazodone is 400 mg per day, although people who have been hospitalized due to depression may take up to 600 mg per day.

Trazodone Dosage for Insomnia

Even though trazodone is not approved to treat insomnia, it is frequently prescribed in an "off-label" fashion for this use. Usually, the dose of trazodone for insomnia is lower, starting with 25 mg or 50 mg at bedtime.

General Information on Your Trazodone Dosage

Considerations for people taking trazodone include the following:
  • It usually takes a week or two (or perhaps even more than a month) before feeling the beneficial effects of trazodone. Try not to be discouraged if the drug does not work right away for you.
  • It is best to take your trazodone dosage after a meal or snack. Your system absorbs the medicine better after eating.
  • Trazodone should be taken at the same time(s) each day to maintain an even level in your blood.
  • For the medication to work properly, you have to take it as prescribed. Trazodone will not work if you take it differently from how your healthcare provider recommends.
  • If you are unsure about anything related to your trazodone doses, talk to your doctor, nurse, or pharmacist. Do not stop taking the medication without first discussing it with your healthcare provider.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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