Depression Home > Trazodone Side Effects

Common side effects of trazodone include lightheadedness, dry mouth, and drowsiness. Rare problems (reported in less than 1 percent of people) include numbness, increased salivation, and feelings of internal jitteriness. Although side effects are generally minor and do not require treatment, let your healthcare provider know immediately if you experience a rapid heart rate, chest palpitations, or hallucinations.

An Introduction to Trazodone Side Effects

As with any medicine, side effects are possible with trazodone hydrochloride (Desyrel®). However, not everyone who takes the antidepressant will have problems. In fact, most people tolerate it quite well. If side effects do occur, they are minor in most cases and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with trazodone. Your healthcare provider can discuss a more complete list of side effects with you.)

Serious Side Effects of Trazodone

Some trazodone side effects, while not as common, are potentially serious and should be reported to your healthcare provider. These include but are not limited to:
  • Suicidal thoughts or behavior (see Trazodone and Suicide)
  • A painful erection of the penis that does not go away (priapism)
  • Anxiety, agitation, or panic attacks
  • Hostility or aggressiveness
  • Engaging in unusual or dangerous activities
  • Restlessness or inability to sit still
  • Extreme elation or feeling of happiness that may switch back and forth with a depressed or sad mood
  • Other unusual changes in behavior
  • Hallucinations
  • Fast heart rate
  • Chest palpitations
  • Difficulty sleeping
  • Signs of an allergic reaction, such as:
    • Unexplained rash
    • Hives
    • Itching
    • Unexplained swelling
    • Wheezing
    • Difficulty breathing or swallowing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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