Depression Home > Trimipramine

Trimipramine is a medication used for the treatment of depression in adults. It is a type of tricyclic antidepressant that works by affecting certain chemicals in the brain. Some possible side effects of trimipramine include dizziness, dry mouth, and constipation. The capsules, which are available by prescription, come in three different strengths and are generally taken one to four times a day.

What Is Trimipramine?

Trimipramine maleate (Surmontil®) is a prescription medication used to treat depression (also known as major depression or clinical depression).
(Click What Is Trimipramine Used For? for more information on this topic, including possible off-label uses.)

Who Makes It?

Trimipramine is made by Duramed Pharmaceuticals.

How Does Trimipramine Work?

Trimipramine belongs to a class of medications called tricyclic antidepressants. It is not entirely clear how this medicine works. However, it is known to affect several chemicals in the brain, including serotonin and norepinephrine. It is thought that perhaps trimipramine allows these chemicals to stay in the brain longer, which can help with depression symptoms.

When and How to Take This Medication

Some considerations to keep in mind during treatment with trimipramine include the following:
  • This medicine comes in capsule form. When used for depression, it is usually taken by mouth one to four times daily.
  • You can take trimipramine with or without food. If it upsets your stomach, try taking it with food.
  • Trimipramine should be taken at the same time(s) each day to maintain an even level in your blood.
  • For the antidepressant to work properly, you have to take it as prescribed. It will not work if you stop taking it.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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